Seeds from Azadirachta indica— AKA Indian purple, neem tree or margosa – contains a useful natural product called neem oil. It has a variety of health applications, from moisturizing and conditioning skin and hair, to reducing scalp itching and dandruff, to promoting dental and gum health.
It is impressive also a potent natural pesticide, not because it kills by contact, but because it triggers hormonal changes that can interfere with the biological processes of insects.
Finally, the antifungal compounds make nimbin and azadirachtin neem oil a powerful detergent. You can mix in a shampoo for your mat or dilute it with water (about a tablespoon of oil for each cup of water) and spray it on mattresses or furniture to kill microbial pests.